The Root Causes of High Cholesterol (It’s Not Just Saturated Fat)

by Dr. Nick Zyrowski February 02, 2026

For decades, saturated fat has been blamed as the primary cause of high cholesterol and heart disease. Red meat, butter, eggs, and full-fat dairy were labeled the villains, while low-fat, processed alternatives were marketed as “heart healthy.”

But modern research tells a much more nuanced story.

Cholesterol imbalance is rarely caused by one food alone. In fact, many people with elevated cholesterol levels eat relatively well, while others consuming high amounts of processed foods show the greatest risk. The truth is that cholesterol issues are more often driven by inflammation, metabolic dysfunction, lifestyle habits, and toxic exposures, not quality animal foods.

Let’s break down what really drives high cholesterol and what you can do to support healthier lipid levels naturally.

First, Let’s Clear Up the Saturated Fat Myth

Not all saturated fat is created equal.

High-quality grass-fed red meat and pasture-raised dairy provide essential nutrients like:

  • Fat-soluble vitamins (A, D, K2)
  • Conjugated linoleic acid (CLA)
  • Zinc, iron, and B vitamins
  • Healthy fatty acid profiles 

When sourced properly and consumed as part of a whole-food diet, these foods do not automatically raise cardiovascular risk. In fact, cholesterol itself is essential; it supports hormone production, cell membrane integrity, brain health, and vitamin absorption.

The real problem isn’t cholesterol; it’s how cholesterol behaves in the body, especially when inflammation and oxidative stress are present.

The Real Root Causes of High Cholesterol

1. Chronic Inflammation 

Inflammation alters how cholesterol particles function. When LDL particles become oxidized, they are more likely to contribute to plaque formation in arteries.

Inflammation is often driven by:

  • Processed foods
  • Refined sugars
  • Industrial seed oils 
  • Chronic stress
  • Poor gut health
  • Environmental toxins 

Reducing inflammation is one of the most powerful ways to support healthier cholesterol patterns.

2. Trans Fats & Ultra-Processed Foods 

If there’s one dietary culprit strongly linked to poor cholesterol markers, it’s trans fats and highly processed foods.

These are commonly found in:

  • Fried foods
  • Packaged snacks
  • Margarines and shortening
  • Commercial baked goods
  • Fast food 

Trans fats raise LDL (“bad”) cholesterol, lower HDL (“good”) cholesterol, and significantly increase cardiovascular risk. Removing these foods alone can dramatically improve lipid profiles. If you need help with cooking in a healthy way, we create monthly meal plans that keep your time in the kitchen low, but your nutritional quality high. 

3. Insulin Resistance & Blood Sugar Imbalance

High cholesterol often travels alongside insulin resistance and metabolic dysfunction.

Excess sugar and refined carbohydrates can: 

  • Increase triglycerides
  • Promote fatty liver
  • Shift LDL particles toward more dangerous forms
  • Reduce HDL levels 

This is why many people see cholesterol improve when they address blood sugar regulation, not just fat intake.

 4. Lack of Physical Activity

Movement plays a major role in cholesterol metabolism.

Regular activity:

Increases HDL cholesterol Improves insulin sensitivity Enhances circulation Supports liver function (where cholesterol is processed)

Even moderate, consistent movement, like a 30 minute brisk walk a day, can positively impact cholesterol markers.

5. Excess Body Weight

Carrying excess weight, particularly visceral fat around the abdomen, contributes to inflammation and worsens lipid profiles.

This isn’t about aesthetics; it’s about metabolic health. Supporting sustainable weight balance through nutrition, movement, sleep, and stress management can improve cholesterol naturally.

6. Chronic Stress

Stress has a direct biochemical impact on cholesterol.

Elevated cortisol:

  • Increases inflammation
  • Disrupts blood sugar regulation
  • Alters lipid metabolism
  • Impairs liver detoxification 

Long-term stress without proper recovery can sabotage cholesterol even in those eating a relatively healthy diet. 

7. Alcohol & Smoking

Both alcohol and smoking negatively impact cholesterol and cardiovascular health. Even though we know this, it is often a difficult thing to remove from our lives. But if cholesterol is a concern of yours, you’ll want to kick this habit, and fast.

  • Excess alcohol raises triglycerides and promotes fatty liver
  • Smoking oxidizes LDL particles and damages blood vessels 

Reducing or eliminating these habits can lead to significant improvements over time.

Why the Liver Matters More Than You Think

Your liver plays a central role in cholesterol production, recycling, and elimination.

When liver detoxification pathways are overwhelmed, due to toxins, poor diet, inflammation, or nutrient deficiencies, cholesterol balance can suffer. Supporting liver health is a foundational step in any cholesterol strategy. In our clinic, we use Liver Assist to aid in a healthy functioning liver.

Targeted Nutritional Support: Cholesterol Care Kit

Lifestyle changes are essential, but targeted supplementation can help address cholesterol at the root—especially when inflammation, oxidative stress, and metabolic imbalance are involved.

Your Cholesterol Control Pack was designed to do exactly that by supporting:

  • Healthy cholesterol metabolism
  • Liver function
  • Inflammatory balance
  • Cardiovascular health 

Rather than simply “lowering numbers,” this approach focuses on optimizing how cholesterol functions in the body, supporting long-term heart health without extreme dietary restriction.

A Smarter Approach to Cholesterol Health

High cholesterol isn’t a moral failure, and it isn’t caused by one food group.

The most effective strategy focuses on:

  • Reducing inflammation
  • Eliminating processed foods and trans fats
  • Supporting blood sugar balance
  • Managing stress Moving your body regularly
  • Supporting liver and cellular health
  • Using targeted supplements when appropriate 

When you address the root causes, cholesterol often improves as a downstream effect.

 Final Thoughts

Cholesterol isn’t the enemy, it’s a vital molecule. The real issue is metabolic stress, inflammation, and modern lifestyle factors that disrupt balance.

By shifting the focus from fear-based nutrition to root-cause healing, you can support healthier cholesterol levels while still enjoying nutrient-dense, whole foods—including high-quality red meat and dairy.

If you’re ready to take a smarter, more comprehensive approach, the Cholesterol Control Pack provides targeted support alongside lifestyle changes that actually work.

Dr. Nick Zyrowski
Dr. Nick Zyrowski