Benefits of One Meal A Day (OMAD): A Deep Dive into This Advanced Fasting Approach

by Dr. Nick Zyrowski May 26, 2025

One Meal a Day (OMAD) is an advanced intermittent fasting method where all your daily calories are consumed within a single meal. After that meal, you fast for the remaining 23 hours. It might sound extreme at first, but for many people, OMAD is a powerful tool for improving physical health, boosting mental performance, and simplifying life.

OMAD isn’t for everyone, but if done correctly—with proper nutrition and under the right circumstances—it can unlock some remarkable benefits. Let’s explore the top scientifically-backed and anecdotal benefits of the OMAD lifestyle.

🔥 1. Accelerated Fat Loss

One of the primary reasons people turn to OMAD is to lose fat efficiently—and it’s easy to see why.

During a prolonged fast, your body transitions into ketosis, a fat-burning state where it uses stored fat for fuel instead of glucose. Because you're fasting for 23 hours, your body spends more time in this fat-burning mode compared to shorter fasting windows (like 16:8 or 18:6).

Additionally, eating only once keeps insulin levels low for most of the day. Insulin is a storage hormone that, when elevated, promotes fat storage. By minimizing insulin spikes, OMAD encourages your body to tap into stored fat more consistently.

Key takeaway: The extended fasting window with OMAD maximizes fat oxidation, making it a highly effective strategy for those looking to shed excess body fat.

 🧠 2. Mental Clarity and Focus

While food provides energy, digestion also diverts blood and energy toward the gut. By minimizing digestion throughout the day, many OMAD practitioners report enhanced mental clarity, sharper focus, and fewer energy crashes.

When your body isn't busy breaking down food, it can allocate more resources to the brain. Furthermore, being in ketosis (common during the fasting portion of OMAD) supplies the brain with ketones, which are a highly efficient and stable energy source.

People often describe it as feeling “clear-headed” or “laser-focused,” especially during the hours leading up to their meal.

Fun fact: Many high-performing individuals—from Silicon Valley entrepreneurs to athletes—use fasting to boost mental performance during work or training hours.

 🍽️ 3. A Simplified Lifestyle

Let’s be honest—eating three meals a day (plus snacks) takes time and energy. Cooking, cleaning, grocery shopping, planning meals...it all adds up.

With OMAD, you only need to think about one meal each day.

You prepare one nutrient-dense meal, enjoy it, clean up, and you’re done. For many, this creates a sense of freedom and simplicity that reduces stress around food. No more worrying about macros for multiple meals or figuring out lunch on the go.

It’s minimalism for your diet—and it’s a breath of fresh air for people who prefer a more streamlined daily routine.

 💪 4. Improved Insulin Sensitivity

Prolonged fasting—like that involved in OMAD—has been shown to improve insulin sensitivity, which means your cells respond more efficiently to insulin when it’s present. This is incredibly important because poor insulin sensitivity (or insulin resistance) is a major driver of:

  • Weight gain
  • Type 2 diabetes
  • Fatigue
  • Inflammation

Eating once and allowing a long fasting period gives your body a break from constant insulin spikes. Over time, this can help stabilize blood sugar, reduce cravings, and improve how your body processes carbohydrates.

Health ClubPerspective: OMAD can be a useful tool for clients looking to regain control of their blood sugar or reverse early metabolic dysfunction—when paired with a nutrient-dense meal and proper professional guidance.

 🧬 5. Autophagy and Cellular Repair

One of the lesser-known—but most profound—benefits of fasting is the activation of autophagy. This is the body’s built-in “cellular recycling” process where it removes old, damaged cells and regenerates healthier ones.

Autophagy is linked to: 

  • Anti-aging effects
  • Reduced inflammation
  • Lower risk of chronic diseases like cancer, Alzheimer’s, and cardiovascular disease

OMAD, with its extended fast, provides ample time for autophagy to take place, especially when you’re deep into the fasted state. It’s like giving your body a regular tune-up.

Think of it this way: You’re not just skipping meals—you’re turning on your body’s internal repair system.

 💥 6. Support for Hormone Balance

Fasting doesn’t just affect insulin—it also plays a role in regulating several other key hormones:

  • Leptin (satiety hormone): becomes more responsive, helping you recognize fullness
  • Ghrelin (hunger hormone): becomes less erratic, reducing constant cravings
  • Cortisol (stress hormone): tends to normalize with consistent fasting routines

For many, OMAD leads to a rebalanced hunger/fullness cycle. Instead of constantly feeling “snacky,” your appetite becomes more predictable and manageable. This is especially helpful for individuals with leptin resistance or disrupted eating patterns.

Some practitioners even report improvements in thyroid health and sex hormones over time, although this should always be monitored with the help of a qualified healthcare provider.

 🩺 7. Cardiovascular Benefits

 OMAD may positively impact heart health by improving several key biomarkers:

  • Lower blood pressure: Fasting has a natural blood pressure-lowering effect in many people.
  • Improved cholesterol: Including increased HDL (good cholesterol) and decreased LDL (bad cholesterol) particles, particularly the small, dense kind associated with heart disease.
  • Lower triglycerides: Especially when the one meal is rich in healthy fats and fiber.

Combined with weight loss and reduced inflammation, OMAD can support a more heart-healthy profile—though it’s important to approach it carefully and monitor changes.

Pro Tip: Include foods like wild salmon, olive oil, avocados, leafy greens, and walnuts to enhance these benefits.

 ⚠️ Important Considerations

OMAD can be powerful—but it’s not for everyone. Here are a few important notes before diving in:

❌ Who Should Avoid OMAD:

Highly active individuals: Athletes or people with physically demanding jobs may need more frequent meals for recovery and performance.

People with hormone imbalances: Especially women with adrenal fatigue or thyroid conditions—fasting may aggravate symptoms.

Those with a history of eating disorders: Restrictive eating patterns can be triggering and dangerous.

Pregnant or breastfeeding women: Nutritional demands are higher and fasting is generally not recommended.

✅ How to Do OMAD the Right Way:

Nutrient density is non-negotiable. You’re only eating once, so that meal must be rich in:

  •  High-quality protein 
  •  Healthy fats (avocados, olive oil, omega-3s)
  •  Complex carbs/fiber (veggies, resistant starches)
  •  Micronutrients (magnesium, potassium, zinc, etc.)
  1. Stay hydrated throughout the day with water, herbal teas, or black coffee.
  2.  Listen to your body. Some people thrive on OMAD; others feel depleted. Adjust based on your energy, sleep, and overall well-being.
  3.  Work with a professional if you have medical conditions or are taking medications.

Final Thoughts

One Meal a Day isn’t just about eating less—it’s about eating intentionally. When done right, OMAD can support fat loss, boost brain function, regulate blood sugar, and even promote longevity through cellular repair. It also adds a layer of simplicity that can be liberating in a busy, food-obsessed culture.

But remember: OMAD is a tool, not a one-size-fits-all solution. It works best when paired with nutrient-dense foods, proper guidance, and respect for your body’s unique needs.

If you’re considering OMAD, start slow—perhaps with a 16:8 fasting approach—and build up as your body adapts. And if it feels right, that one daily meal could become your most powerful wellness ritual.

Dr. Nick Zyrowski
Dr. Nick Zyrowski