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Power C provides 3,000mg of vitamin C buffered with minerals and delivered in a delicious fruit punch-flavor that mixes perfectly in water. Power C is filled with antioxidant activity that is well-suited for those seeking high-potency vitamin C to support immune health.
Vitamin C (ascorbic acid) is a powerful water-soluble nutrient with various physiological functions and is essential to human health. Unlike other mammals, humans are unable to synthesize vitamin C as needed and must obtain in through outside sources and supplementation. Vitamin C is the primary aqueous phase antioxidant. It is necessary for the development and maintenance of collagen, cartilage, and blood vessels. It is also critical for the absorption of iron, for the synthesis of carnitine, neurotransmitters, and as a cofactor for metabolic enzymes and plays a significant tole in immune system function (1,3)
Free radical production has been shown to increase when exposed to physiological, psychological, chemical or emotional stressors. Vitamin C works in an aqueous environment both inside and outside cells as first line of cellular antioxidant defense, and is able to quench free radicals that have the potential to damage, proteins, and membrane structure (1,4). Oxidative stress also occurs if antioxidant defenses are impaired, which may be the case when vitamin C levels are insufficient (1,5). Vitamin E and carotenes (lipid phase antioxidants) are vitamin C's non-enzymatic antioxidant partners. They work in concert with the antioxidant enzymes glutathione peroxidase, catalase, and superoxide dismutase. Vitamin C is also responsible for regenerating oxidized vitamin E in the body, thus potentiating the antioxidant benefits of vitamin E (3,6).
Vitamin C's antioxidant role is recognized as critical to the health of the immune system. Vitamin C supports epithelial barrier function and promotes oxidant scavenging activity in the skin to help protect against environmental oxidative stress (1). In addition, vitamin C is absorbed by immune cells and works to boost T-lymphocyte activity, phagocyte function, leukocyte mobility, and possibly antibody and interferon production (3,5,7).
Much debate remains on the issue of how much vitamin C is required to ensure that immunity is not compromised. It only takes 10 mg of daily vitamin C to prevent scurvy, which results in poor wound healing and weakened immunity (1,8). The current RDA for vitamin C is 75 mg/day for adult women and 90 mg/day for adult men with an additional 35 mg/day recommended for smokers. The tolerable upper intake levels (UL) of 2,000 mg/day was established based on the potential risk for gastrointestinal disturbances in some individuals at high doses, however, doses of up to 10g/day in adults have not proven to be toxic or detrimental to health (3). Due to the fact that vitamin C is water-soluble, excess levels get excreted once tissues have become saturated. This is why it is often suggested to take vitamin C throughout the day to maintain serum levels. Pharmacokinetic studies have explored various doses to determine where saturation begins to happen. At in intake of 22 mg/day, no vitamin C was excreted in the urine; whereas, when intake was increased to 500 mg/day, excretion did occur. These studies have led some experts to recommend that the RDA be increased to 200 mg/day with no more than 500 mg/day needed. Other advocates that doses of ascorbic acid above 1,000 mg/day are necessary for maintain tissue saturation. Although there are only a few randomized controlled trials with large daily doses of vitamin C, pharmacokinetic data indicates that daily oral doses up to 2,500 mg/day results in higher plasma ascorbate levels than doses of 200 mg/day, despite increases urinary excretion (9,10).
The work of Linus Pauling published in 1070 produced great public interest and kicked off decades of studies assessing the link between high-dose vitamin C and immune health (11). In early 1972, a randomized, double-blind study, placebo controlled study of subjects taking 1,000 mg of vitamin C/day provided support for the use of vitamin C supplementation for common immune challenges. The study revealed that the supplementation group missed significantly fewer days from work/activities and had fewer days per episode of immune challenges. In addition, significantly more taking vitamin C remained symptom-free throughout the study (1,2)
Another prospective, controlled with students ranging from 18 to 32 years old was conducted in a controlled environment to assess the effect of vitamin C megadoses on seasonal immune symptoms. Subjects in the control group group who reported symptoms were given pain relievers and decongestants. In the test group, symptomatic subjects were given hourly doses of 1,000 mg of vitamin C for the first 6 hours followed by three times daily thereafter; non-symptomatic test subjects were given 1,000 mg three times daily. The results suggested that the megadoses of vitamin C were beneficial for both easing and warding off seasonal immune symptoms (13).
Offers 3,000 mg of vitamin C derived from tapioca and buffered with the minerals calcium, magnesium, and potassium. This formula is ideal for individuals seeking supplemental vitamin C in a hypoallergenic, powdered form, and it is suitable for those with sensitivity to high dosages of vitamin C.
Does Not Contain: Wheat, gluten, yeast, soy, corn, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
Suggested Use: Mix the contents of one stick (7g) with 6-8 oz of cold water and consume daily, or as directed by your healthcare professional.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
References
1. Carr AC, Maggini S. Nutrients. 2017;9(11):1211. doi:10.3390/nu9111211. 2. Lee JK, Jung SH, Lee SE, et al. Korean J Physiol Pharmacol. 2018;22(1):35-42. doi:10.4196/kjpp.2018.22.1.35. 3. inus Pauling Institute. Vitamin C. http://lpi.oregonstate.edu/infocenter/vitamins/vitaminC/. Updated July 2018. Accessed January 13, 2021. 4. Gruenwald J, Graubaum HJ, Busch R, et al. Adv Ther. 2006;23:171-178. doi:10.1007/BF02850358. 5. Bucher A, White N. Am J Lifestyle Med. 2016;10(3):181-183. doi:10.1177/1559827616629092. 6. Bendich A, Machlin L, Scandurra O, et al. Free Radical Biol Med. 1986;2:419-444. doi:10.1016/S8755-9668(86)80021-7. 7. Liugan M, Carr AC. Nutrients. 2019;11(9):2102. doi:10.3390/nu11092102. 8. Lykkesfeldt J, Poulsen HE. Br J Nutr. 2010;103(9):1251-1259. doi:10.1017/S0007114509993229. 9. Michels AJ, Frei B. Nutrients. 2013;5(12):5161-5192. doi:10.3390/nu5125161. 10. Levine M, Conry-Cantilena C, Wang Y, et al. Proc Natl Acad Sci U S A. 1996;93(8):3704-3709. doi:10.1073/pnas.93.8.3704. 11. Pauling L. Proc Natl Acad Sci USA. 1970;67(4):1643-8. doi:10.1073/pnas.67.4.1643. 12. Anderson TW, Reid DB, Beaton GH. Can Med Assoc J. 1972;107(6):503-508. 13. Gorton HC, Jarvis K. J Manipulative Physiol Ther. 1999;22(8):530-533. doi:10.1016/s0161-4754(99)70005-9. 14. Hemilä H, Chalker E. Cochrane Database Syst Rev. 2013;(1):CD000980. doi:10.1002/14651858.CD000980.pub4.
