A compound called Berberine is one of the most effective natural supplements available. Berberine has been shown to lower blood sugar, cause weight loss, and improve heart health. One of the main actions of Berberine is to activate the AMPK enzyme, which is sometimes referred to as the "metabolic master switch".
Many studies show that berberine can significantly reduce blood sugar levels in individuals with type 2 diabetes. In fact, its effectiveness is comparable to the popular diabetes drug metformin.
If you want to improve your insulin sensitivity, lower blood sugar naturally, and maintain a healthy body weight, then look to the nutrient berberine. Berberine ER by Celarity is a natural insulin sensitivity supplement designed to help your body regulate insulin levels and balance your blood sugar naturally. Berberine IR was reformulated to Berberine ER and is now 5x more bioavailable.
Berberine ER is designed to support insulin activity and glucose metabolism. Berberine ER features dihydroberberine (DHB), the natural, highly bioactive form of berberine. Research also suggests a role for berberine in supporting normal A1C levels. We recommend that you combine Berberine ER with a low carb diet (like the Heal Yourself Diet) for optimal results.
Berberine ER contains DHB originating from berberine sourced fromBerberis aristataand naturally extracted through an enzymatic process similar to that which occurs in the human gut. With a 5-fold relative increase in absorption rate, supplemental DHB at much lower doses than berberine has comparable beneficial metabolic effects.
Berberine is known as an alkaloid, and plants containing berberine have traditionally been used for their various health-promoting properties. Research has demonstrated that berberine helps regulate glucose and lipid metabolism, positively influences cell signaling, provides antioxidant support, and impacts immune health.[1-3]Of more recent interest is the influence of berberine on cardiometabolic health, including its effects on adenosine monophosphate-activated protein kinase (AMPK), gene transcription and signaling factors that influence adipose tissue differentiation, and hemoglobin A1c (HbA1c) levels.
Adenosine Monophosphate-Activated Protein Kinase (AMPK)
As the primary enzyme that induces an intracellular cascade of events, AMPK is responsible for maintaining and replenishing cellular energy stores. AMPK activation stimulates glucose uptake and fat oxidation while it suppresses lipogenesis and gluconeogenesis. Cumulatively, AMPK activation leads to beneficial metabolic states in liver, muscle, and peripheral tissues. Of the natural products known to activate AMPK, berberine is one of the most prominent. AMPK activation by berberine was reported as early as 2006.Since that time, berberine-mediated AMPK activation has been repeatedly demonstrated, and this mechanism is thought to be central to the beneficial effects on glucose metabolism, insulin sensitivity, cytokine activity, and cardiovascular health observed in patients taking berberine.[3,5,6]
Adipocyte Differentiation and PPAR-Gamma Expression
In vitro, berberine positively influences fat cell size.This effect is significant because it has been reported that fat tissue composed of a high number of small fat cells is more sensitive to insulin than fat tissue (with the same lipid content) composed of a low number of large fat cells. Berberine has also been shown to downregulate the adipogenesis-regulating transcription factors peroxisome proliferator-activated receptor (PPAR) gamma2 and CCAAT/enhancer-binding protein (C/EBP) alpha in preadipocytes isolated from human omental fat.This downregulating effect on PPARs has been observed in other in vitro work and in animal research as well.[8-11]In a human study, individuals taking 900 mg/d of berberine for three months showed decreases in waist circumferences and BMI (body mass index) as well as significant decreases in leptin levels, leptin/adiponectin ratio, and the homeostatic model assessment of insulin resistance (HOMA-IR). There were no significant changes in adiponectin levels.
Hemoglobin A1c (HbA1c)
Also known as glycated hemoglobin or glycosylated hemoglobin, HbA1c serves as the definitive measure of a person’s average blood sugar level for a three-month period. Maintaining HbA1c within a healthy range is an important aspect of cardiometabolic wellness. Recent studies on berberine show that doses of 1,000 to 3,000 mg/d have a positive effect on HbA1c levels. Yin et al demonstrated that 1,500 mg/d of berberine had significant beneficial effects on HbA1c, glucose metabolism, and triglyceride metabolism.In a randomized placebo-controlled study (n = 116), 1,000 mg/d of berberine significantly decreased HbA1c and had positive effects on blood lipid metabolism.This desirable effect on HbA1c by berberine has also been observed in animals.
Recommended Usage:Take one to two capsules daily with food, or as directed by your healthcare practitioner.
Cautions: Consult your healthcare practitioner prior to use. Individuals taking medications, especially medications that are metabolized by cytochrome P450 enzymes or that affect blood glucose, should discuss potential interactions with their healthcare practitioner. Do not use if you are pregnant, nursing, or trying to conceive. Do not use if tamper seal is damaged.
Does Not Contain:Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
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2. Zhang Q, Xiao X, Feng K, et al. Evid Based Complement Alternat Med. 2011;2011:924851. doi:10.1155/2011/924851
3. Yin J, Xing H, Ye J. Metabolism. 2008;57(5):712-17. doi:10.1016/j.metabol.2008.01.013
4. Feng R, Shou JW, Zhao ZX, et al. Sci Rep. 2015;5:12155. doi:10.1038/srep12155
5. Turner N, Li JY, Gosby A, et al. Diabetes. 2008;57(5):1414-1418. doi:10.2337/db07-1552
6. Han J, Lin H, Huang W. Med Sci Monit. 2011;17(7):RA164-RA167. doi:10.12659/msm.881842
7. Zhou L, Yang Y, Wang X, et al. Metabolism. 2007;56(3):405-412. doi:10.1016/j.metabol.2006.10.025
8. Wang Q, Zhang M, Liang B, et al. PLoS One. 2011;6(9):e25436. doi:10.1371/journal.pone.0025436
9. Chen C, Yu Z, Li Y, et al. Am J Chin Med. 2014;42(5):1053-1070. doi:10.1142/S0192415X14500669
10. Gaba S, Saini A, Singh G, et al. Bioorg Med Chem. 2021;38:116143. doi:10.1016/j.bmc.2021.116143
11. Wolf PG, Devendran S, Doden HL, et al. BMC Microbiol. 2021;21(1):24. doi:10.1186/s12866-020-02020-1
12. Moon J, Ratliff K, Hagele A, et al. Nutrients. 2021;14(1):124. doi:10.3390/nu14010124
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.