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Vascular Balance



 

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Description Supplement Facts
 
Vascular Balance is a combination of three incredible, food-derived extracts that have been scientifically proven to support antioxidant activity and nitric oxide synthesis. These two mechanisms are major contributers to both the health of your arteries and the maintenance and balance of blood pressure.

Blood pressure is becoming a major problem…
High blood pressure is a health concern that is growing at an alarming rate. The Center for Disease Control and Prevention reports that 1 in 3 Americans are suffering from high blood pressure. This equates to about 70 million people. Of this 70 million, it is estimated that half of the people have uncontrolled blood pressure, putting you at serious risks for major health problems like:
  1. Heart Disease
  2. Stroke
  3. Kidney Disease
  4. Cognitive Decline; Dementia and Alzheimer’s
Vascular Health (along with high blood pressure) has become a passionate subject for me as I see so many of my own family members, friends and patients struggle to manage and maintain healthy blood pressure levels. Time and time again, I see these people put on high blood pressure mediation with no plan of coming off of them.

There are many strategies that can be used in the holistic realm in order to support healthy blood pressure levels and vascular balance. The good news is that they can be used without all the side effects.

Introducing Vascular Balance
I am very excited about this formula. With Vascular Balance's synergistic blend of scientifically proven ingredients, we now have a strategy backed by science to offer individuals the support they need.

Clinical Applications of Vascular Balance
  • Promotes Healthy Blood Pressure Levels
  • Provides Support for Cardiovascular Health
  • Powerful Antioxidant Support
A Scientific Overview of Ingredients
Each of the food-derived extracts in Vascular Balance offers improvements in clinical markers of vascular health.

Proper function of the endothelium is critical to allow blood vessels to fully dilate as a result of changes in blood flow and to deter constriction of the vessels. Reduced nitric oxide (NO) availability and an imbalance of endothelium-derived relaxing and contracting factors contribute to endothelial dysfunction, which is linked to the development of numerous vascular conditions.[1]

Cordiart™ - It has been suggested that hesperidin alters endothelial cells to allow natural dilation and control of blood flow and pressure. In isolated and cultured endothelial cells, hesperidin stimulates the production of endothelial NO synthase, the NO-producing enzyme that triggers arterial dilation which, in turn, increases healthy blood flow.[2,3]

A randomized, placebo-controlled, double-blind, crossover trial examined whether oral hesperidin administration (500 mg/day for three weeks) improved endothelial function in 24 individuals with metabolic syndrome. The results revealed a significant increase in flow-mediated dilation (FMD) in the metabolic syndrome patients compared to the patients on placebo. [4]

Another name for hesperidin is hesperetin 7-rutinoside. As discussed above, the rutinoside hesperidin is widely studied and has been linked to several major health-promoting effects. However, the low solubility and complex metabolism of rutinosides in the gastrointestinal system have limited their absorption.

Each capsule of Vascular Balance contains 250 mg of Cordiart, a unique pharmaceutical grade rutinoside orange peel extract that contains a high concentration of rutinoside-2S. The high ratio of the more active “S” form in Cordiart makes it unique.

Compared to other rutinoside preparations, which contain nearly equal amounts of the “S” to “R” forms, Cordiart has shown greatly improved bioavailability. [5,6]

Cordiart has been studied for its effect in activating endothelial production of NO. In a randomized placebo-controlled trial, subjects received a three-week intervention of 500 mg/day of Cordiart resulting in an 18% higher FMD score, a direct marker of endothelial function, compared to those receiving placebo.

Additionally, concentrations of high-sensitivity C-reactive protein (hs-CRP) and serum amyloid A (SAA) were reduced as was circulating E-selectin, indicating reduced obstruction of the endothelium. [4]

An additional randomized, double-blind, placebo-controlled study evaluated the effect of 450 mg of daily Cordiart on endothelial function in 68 overweight subjects for a six-week period. Although no significant changes in fasting or postprandial FMD were observed in a group of patients with a baseline FMD of less than 3%, those with a baseline greater than or equal to 3% showed significant improvement in endothelial function.

Circulating adhesion molecules sVCAM-1 and slCAM-1 were reduced along with systolic and diastolic blood pressure in both groups regardless of baseline FMD. The findings suggested that Cordiart has a promising role in the preservation of endothelial function and healthy blood flow in overweight individuals. [7]

Grape Seed Extract - Grape seed extract is a rich source of oligomeric proanthocyanidins (OPCs), which donate electrons or protons to reactive oxygen species (ROS) and act as scavengers.[8]

Oxidative stress can increase vascular endothelial permeability, formation of oxidized LDL, and activation of phagocytic cells. Grape seed extract has been investigated for its ability to interfere with oxidative stress, benefiting cholesterol and blood pressure. [9,10]

When utilized as a dietary supplement, grape seed extract has been suggested for lowering blood pressure in individuals with mildly elevated levels.

In a double-blind placebo-controlled study, supplementing with 300 mg per day of grape seed extract for eight weeks (n=66) resulted in a statistically significant decrease in both systolic (average reduction of 8 mmHg) and diastolic blood pressure (average reduction of 5mmHg) in adults with prehypertension (mildly elevated blood pressure). Levels in the placebo group were not reduced.[11]

In another double-blind placebo-controlled study, 27 subjects with metabolic syndrome were given 150 or 300 mg per day of grape seed extract for four weeks. Both systolic and diastolic blood pressures were lowered after treatment with grape seed extract as compared with placebo. A decrease in oxidation of LDL particles also occurred in the treatment group. [12]

Each capsule of Vascular Balance contains 75 mg of Enovita®, a grape seed extract standardized to 95% proanthocyanidins. Enovita has shown efficacy in maintaining healthy blood pressure when associated with diet and lifestyle modification.

A four-month duration study evaluated two dosages (150 mg/day and 300 mg/day) of Enovita in 119 subjects with borderline hypertension (defined as pre-hypertension) (120-139 mmHg/80-89 mmHg) and stage 1 hypertension (140-159 mmHg/90-99 mmHg).[13] The participants utilized nondrug dietary (reduction in salt, alcohol, and caffeinated drinks) and lifestyle (regular exercise, sleep time improvement, relaxation, and smoking reduction) interventions.

Blood pressure and heart rate were the primary endpoints, with blood pressure normalization being significantly higher in the Enovita supplementation groups compared to control starting from the fourth week of supplementation.[14]

Olive Leaf Extract - The evidence linking the Mediterranean diet to cardiovascular health has grown substantially in recent years[15-17] with specific research suggesting that olive oil and its phenolic constituents are primary beneficial contributors.[18-22]

Phenolic compounds have been shown to have a protective effect against LDL oxidation,[20,23,24] and additional studies have demonstrated the ability of olive leaf extracts to significantly reduce blood pressure measurements.[25] Olive polyphenolic compounds have also been linked to an increase in the production of NO.[26,27]

Each capsule of Vascular Balance provides 125 mg of Arthricor® olive leaf extract with three polyphenols—hydroxytyrosol, oleuropein, and tyrosol at levels supportive of vascular health.

Why Dr. Zyrowski utilizes Vascular Balance Clinically
When people suffer from increased blood pressure, they often do not know the necessary steps to take in order to support a natural balance. This is why utilizing Vascular Balance, along with the Heal Yourself Diet and the removal of caffeine, is the most compelling option they have ever been given. We see people everyday reverse conditions they have been told are non-reversible. Vascular Balance is my first go to when supporting a healthy balanced blood pressure.

Celarity Company Statement
Celarity Vascular Balance is a state of the art product that is pharmaceutical grade and only to be sold by licensed practitioners. Celarity prides itself on being on the forefront of innovation in the natural health and holistic healing field. Celarity also prides itself on working with innovative doctors who are disruptors in the health care field.

References
1. Hadi HA, Carr CS, Al Suwaidi J. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag. 2005 Sep; 1(3):183-198. [PMID: 17319104]

2. Chiou CS, Lin JW, Kao PF, et al. Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells. Clin Exp Pharmacol Physiol. 2008 Aug;35(8):938-43. [PMID: 18430059]

3. Liu L, Xu DM, Cheng YY. Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells. J Agric Food Chem. 2008 Feb 13;56(3):824-9. [PMID: 18197618]

4. Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 2011 May;96(5):E782-92. [PMID: 21346065]

5. Hua S, Song C, Geczy CL, et al. A role for acute-phase serum amyloid A and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis. Redox Rep. 2009;14 (5): 187-96. [PMID: 19843373]

6. BioActor. Cordiart™ Formulation Has a >100% Improved Bioavailability Compared to Standard Rutinoside. Bioavailability Study Report. Maastricht, Netherlands: Bioactor B.V.; 2013. [available on request]

7. Salden BN, Bouke N, Troost FJ, et al. Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals. Am J Clin Nutr. 2016 Dec;104(6):1523-1533. [PMID: 27797708]

8. Cook NC, Samman S. Flavonoids – chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem. 1996;7:66–76. doi:
http://dx.doi.org/10.1016/S0955- 2863(95)00168-9.

9. Lum, H., Roebuck, KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol. 2001 Apr;280(4):C719-C741. [PMID: 11245588]

10. Shi J, Yu J, Pohorly JE, et al. Polyphenolics in grape seeds—biochemistry and functionality. J Med Food. 2003 Winter;6(4):291-9. [PMID: 14977436]

11. Robinson M, Lu B, Edirisinghe I, et al. Effect of grape seed extract on blood pressure in subjects with pre-hypertension. J Pharm Nutr Sci. 2012;2(2):155-159.
http://dx.doi.org/10.1016/S0955- lifescienceglobal.com/pms/index.php/jpans/article/view/916/411. Published May 11, 2012. Accessed May 7, 2017.

12. Sivaprakasapillai B, Edirisinghe I, Randolph J, et al. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009 Dec;58(12):1743- 1746. [PMID: 19608210]

13. Pimenta E, Oparil S. Management of hypertension in the elderly. Nat. Rev Cardiol. 2012 Mar 13;9(5):286-96. [PMID: 22411292]

14. Belcaro G, Ledda A, Hu S, et al. Grape seed procyanidins in pre-and mild hypertension: a registry study. Evid Based Complement Alternat Med. 2013;2013:313142. [PMID: 24171039]

15. Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013 Apr 4;368(14):1279-90. [PMID: 23432189]

16. Mayor S. Mediterranean diet reduces cardiovascular events in people with heart disease, study shows. BMJ. 2016 Apr 24;353:i2348. [PMID: 27114468]

17. Chiva-Blanch G, Badimon L, Estruch R. Latest evidence of the effects of the Mediterranean diet in prevention of cardiovascular disease. Curr Atheroscler Rep. 2014 Oct;16(10):446. [PMID: 25115436]

18. Fitó M, Cladellas M, de la Torre R, et al. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Eur J Clin Nutr. 2008 Apr;62(4):570-74. [PMID: 17375118]

19. Ruano J, López-Miranda J, de la Torre R, et al. Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients. Am J Clin Nutr. 2007 Aug;86(2):341-46. [PMID: 17684203]

20. Gimeno E, de la Torre-Carbot K, Lamuela-Raventós RM, et al. Changes in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trial. Br J Nutr. 2007 Dec;98(6):1243-50. [PMID: 17617938]

21. Bogani P, Galli C, Villa M, et al. Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis. 2007 Jan;190(1):181-86. [PMID: 16488419]

22. Guasch-Ferré M, Hu FB, Martínez-González MA, et al. Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. BMC Med. 2014 May 13;12:78. [PMID: 24886626]

23. Castañer O, Covas MI, Khymenets O, et al. Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans. Am J Clin Nutr. 2012 May;95(5):1238-44. [PMID: 22440854]

24. Raederstorff D. Antioxidant activity of olive polyphenols in humans: a review. Int J Vitam Nutr Res. 2009 May;79(3):152-65. [PMID: 20209466]

25. Cherif S, Rahal N, Haouala M, et al. A clinical trial of a titrated Olea extract in the treatment of essential arterial hypertension. J Pharm Belg. 1996 Mar-Apr;51(2):69-71. [PMID: 8786521]

26. Visioli F, Bellosta S, Galli C. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci. 1998;62(6):541-6. [PMID: 9464466]

27. Rocha BS, Gago B, Barbosa RM, et al. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology. 2009 Nov 9;265(1-2):41- 8. [PMID: 19778575]

Count:
60 vegetarian capsules

Recommended Use: Take one capsule twice daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Does not contain: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

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