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S-Acetyl Glutathione is a highly bio-available form of glutathione, the body's strongest antioxidant. Glutathione not only protects us from certain types of diseases but it also treats cognitive problems, from autism to Alzheimer’s disease, and a wide array of other health problems. In fact, maintaining high levels of glutathione is essential to chronic disease management and recovery. Taking S-Acetyl Glutathione supplement is a great way to protect ourselves from health problems associated with aging, poor lifestyle and adverse environmental factors.
S-Acetyl Glutathione is an acetylated form of glutathione. This form is well-absorbed, highly bioavailable, and more stable throughout the digestive tract than other forms on the market.
Supplementing with glutathione can significantly increase circulating levels of glutathione in the body. [1,4,5] Glutathione is the body's most important antioxidant. Glutathione is known to neutralize free radicals (thereby fighting cellular damage), promotes detoxification, is essential for immune health, combats oxidative stress, and promotes longevity.
S-Acetyl Glutathione has the ability to permeate into the membrane of mitochondria where it helps maintain its integrity and function. It can also cross the blood-brain barrier allowing it to directly detoxify and protect the brain. In addition, S-Acetyl glutathione has been found to increase intracellular glutathione and improve many biomarkers of oxidative stress. Supplementing with S-Acetyl Glutathione has been shown to support neuron health, liver function, and immune system health.
HIGHLIGHTS
S-ACETYL GLUATHIONE AND AGING
Our body produces its own glutathione; however, its amount diminishes with poor diet, stress, infection and exposure to toxins, pollution, and radiation. It also starts to deplete at the age of 45. Research shows that healthy young people have high levels of glutathione while unhealthy elderly have low levels of this antioxidant, and it is even lower among sick and hospitalized elderly. With low levels of glutathione in the body, we become more prone to infection and diseases as we lack the ability to effectively detoxify. This also causes damage to the liver which further undermines the detoxification process.
To maintain optimum mental and physical function, it is essential to keep high levels of glutathione even before we reach the age of 45 as we are now more exposed to several environmental factors that speed up the depletion of glutathione in our body. Taking glutathione supplements along with consuming glutathione-boosting food and exercise is a good option.
Glutathione may be taken orally or through inhalation or injection. Several oral glutathione supplements are available on the market but there are questions as to their bioavailability. When glutathione reaches the stomach, it is broken down and becomes ineffective. A more absorbable and highly stable form of glutathione, S-Acetyl Glutathione, is now available.
S-ACETYL GLUTATHIONE AND DETOXIFICATION
Taking S-Acetyl Glutathione is important for detoxification. A variety of factors may determine glutathione requirements, including level of exposure to toxins, increased phase I detoxification activity, and overall need for antioxidant support. When you take s-acetyl glutathione, glutathione is incorporated into crucial antioxidant enzymes (e.g., glutathione peroxidase and glutathione reductase) and detoxification enzymes (glutathione S-transferases). Through the activity of these enzymes, glutathione directly supports antioxidant activity, phase II detoxification, and the normal breakdown of metabolites, toxins, and other compounds in the body. Glutathione also participates in fatty acid synthesis and amino acid transport across the cell membrane.[1]
The liver and kidneys are two of the main detoxification organs in the body. NAC also has applications in preventing or diminishing liver and kidney damage due to its antioxidant and anti-inflammatory properties.[15]
S-ACETYL GLUTATHIONE AND IMMUNE FUNCTION
Since glutathione is the most powerful antioxidant in the human body, boosting glutathione levels positively impact the function of the overall body. And this includes the immune system. Increased levels of glutathione in the body improves immune function.
Count: 60 capsules
Recommended Usage:Take one to two capsules one to two times daily, or as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.
Does Not Contain:Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
References:
1. Krinsky DL, LaValle JB, Hawkins EB, et al. Natural Therapeutics Pocket Guide. 2nd ed. Hudson (OH): Lexi-Comp; 2003.
2. Locigno R, Pincemail J, Henno A, et al. S-Acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int J Oncol.2002 Jan;20(1):69-75. [PMID: 11743644]
3.Lomaestro BM, Malone M. Glutathione in health and disease: pharmacotherapeutic issues.Ann Pharmacother.1995 Dec;29(12):1263-73. [PMID: 8672832]
4. Ottenwalder H, Simon P. Differential effect of N-acetylcysteine on excretion of the metals Hg, Cd, Pb and Au. Arch Toxicol. 1987 Jul;60(5):401-2. [PMID: 3662815]
5. Keogh JP, Steffen B, Siegers CP. Cytotoxicity of heavy metals in the human small intestinal epithelial cell line I-407: the role of glutathione. J Toxicol Environ Health. 1994 Nov;43(3):351-9. [PMID: 7966443]
6.Richman PG, Meister A. Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.J Biol Chem.1975 Feb 25;250(4):1422-26. [PMID: 1112810]
7.Anderson ME, Powrie F, Puri RN, et al. Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.Arch Biochem Biophys.1985 Jun;239(2):538-48. [PMID: 4004275]
8.Anderson ME, Nilsson M, Sims NR. Glutathione monoethyl ester prevents mitochondrial glutathione depletion during focal cerebral ischemia.Neurochem Int.2004 Feb;44(3):153-59. [PMID: 14568558]
9.Kretzschmar M. Regulation of hepatic glutathione metabolism and its role in hepatotoxicity.Exp Toxicol Pathol. 1996 Jul;48(5):439-46. [PMID: 8765689]
10.Fraternale A, Paoletti MF, Casabianca A, et al. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules.Curr Med Chem.2006;13(15):1749-55. [PMID: 16787218]
11.Kretzschmar M, Klinger W. The hepatic glutathione system—influences of xenobiotics.Exp Pathol. 1990;38(3):145-64. [PMID: 2192911]
12.Donnerstag B, Ohlenschlager G, Cinatl J, et al. Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy.Cancer Lett. 1996 Dec;110(1-2):63-70. [PMID: 9018082]
13.Vogel J, Cinatl J, Dauletbaev N, et al. Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection.Med Microbiol Immunol. 2005 Jan;194(1-2):55-59. [PMID: 14624358]
14. Cacciatore I, Cornacchia C, Pinnen F, et al. Prodrug approach for increasing cellular glutathione levels.Molecules.2010 Mar 3;15(3):1242-64. [PMID: 20335977]
15. De Andrade KQ, et al. Oxidative stress and inflammation in hepatic diseases: Therapeutic possibilities of n-acetylcysteine. Int J Mol Sci. 2015 Dec 18; 16(12): 30269-308. [PMID: 26694382]
16.Ballatori N, Krance SM, Notenboom S, et al. Glutathione dysregulation and the etiology and progression of human diseases.Biol Chem. 2009 Mar;390(3):191- 214. [PMID: 19166318]
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
