Humans are genetically designed to produce sufficient levels of vitamin D3 via the conversion of cholesterol in a reaction that requires exposure of our skin to the sunlight. Over time, our eating patterns have changed and our sun exposure has dwindled (most wear sunscreen or are indoors much of the time). As a result, our Vitamin D levels and our health have declined. Without supplementation, it's nearly impossible to get adequate vitamin d levels.
In a literature review in the journal Epidemiology and Infection, Dr. Cannell wrote on the importance of vitamin D3 for immune system function and the relationship between vitamin D3 deficiency in winter months and influenza (flu) outbreaks. It has been found that vitamin D3 dramatically reduces the incidence of colds and flu.
WHAT IS D3 K2?
D3 K2 by Celarityfeatures the most bioavailable and bioactive form of supplemental vitamin K2 available and vitamin D3 (cholecalciferol). This is the identical form in which vitamin D is derived in the body from cholesterol and synthesized by sunlight on the skin. Studies have confirmed the safety and efficacy for bone and heart health.
To find out if you're deficient in vitamin D, we recommend this easy, at-home Vitamin D Test.
INGREDIENTS THAT WORK
Naturally occurring vitamin K is found as either K1 (phylloquinone), which is derived from food sources such as green leafy vegetables, or K2 (menaquinones). Menaquinones are designated as MK-n, where n denotes the length of the molecule’s aliphatic side chain. Menaquinones are synthesized by bacteria and can be obtained from animal-based and fermented foods. Structural differences between K1 and K2 impact their bioavailability and bioactivity. Furthermore, among menaquinones, menaquinone-7 (MK-7), with its longer side chain, is very hydrophobic. Compared to K1, MK-7’s physiochemical properties make it highly transportable by plasma lipoproteins, increase its extrahepatic (bones, arteries, etc.) availability, and produce its long half-life.[1-3]
Absorption of K1 from food can be limited due to its membrane-bound nature and the individual consumer’s digestive and absorptive variability. Moreover, adequate consumption of foods high in K2 can be challenging. Therefore, dietary supplementation is an important option. In addition, research suggests that higher levels of menaquinones are needed than were previously thought. Supplementary vitamin K can be found in three forms: synthetic K1; MK-4, which is structurally similar to K1; and natural, long-chain MK-7. Celerity's D3 K2 supplement provides MK-7 as Vitamk7TM, a naturally derived and solvent-free vitamin K2 that has been obtained through a patent-granted biofermentation process of Bacillus subtilis natto cultures.
Among the dietary factors critical to bone health, vitamin K has emerged as a key player. Vitamin K is believed to be necessary for bone mineralization. Through carboxylation, vitamin K activates osteocalcin, the protein needed to bind calcium to the mineral matrix in bone. Several studies have demonstrated the efficacy of MK-7 (e.g., doses of 45-90 mcg/d) to increase osteocalcin carboxylation and to increase the cOC:ucOC ratio. A high cOC:ucOC ratio is associated with bone health.[1,2,4] A recent in vitro study also showed an osteogenic effect of MK-7 administration on human mesenchymal cell differentiation. In addition, the vitamin may protect bone integrity by reducing the synthesis of prostaglandin E2 or interleukin-6 by osteoclasts. Animal and human studies have demonstrated a significant beneficial effect of MK-7 supplementation on bone health.[8-10] Vitamin K and vitamin D share some similar characteristics and are believed to act synergistically.
CARDIOVASCULAR AND OTHER HEALTH BENEFITS
Vitamin K benefits cardiovascular health by participating in the carboxylation of matrix GLA protein (MGP), a protein regarded to be the most potent inhibitor of arterial calcification. Researchers have demonstrated that supplementation with vitamin K reduces arterial calcium deposits[1,3,12] and that long-term intake of long-chain menaquinones is inversely correlated with calcium accumulation in arteries.
Vitamin K has specific receptor binding sites that allow it to regulate gene activity. Besides its gene-mediating effects upon critical proteins, the vitamin can also bind with the steroid and xenobiotic receptors and influence their expression. In addition, vitamin K also demonstrates antioxidant activity; reduces levels of certain markers, such as acute phase reactants (e.g., C-reactive protein); and participates in the induction of apoptosis.
VITAMIN D (as D3)
Although vitamin D3 (cholecalciferol) is made in the skin when 7-dehydrocholesterol reacts with sunlight, many things affect the degree to which this biosynthesis occurs, including time of day, seasons, location, smog/ pollution, clothing, shade of skin (darker skin requires more sun), and sunscreen use. Low-cholesterol diets and certain cholesterol therapies can also affect vitamin D formation. By some estimates, one billion people worldwide have vitamin D deficiency or insufficiency. The body needs vitamin D to absorb calcium, and the importance of vitamin D in skeletal health and bone density is well-established. Without adequate absorption, the body must take calcium from its stores in the skeleton, which weakens existing bone and prevents the formation of strong, new